Excerpted Script
"Glucocorticoids plus N-Acetylcysteine in Severe Alcoholic Hepatitis"
by Eric Nguyen-Khac, from Amiens University Hospital, France.
Mortality among patients with severe acute alcoholic hepatitis is high, even among those treated with glucocorticoids. These authors investigated whether combination therapy with glucocorticoids plus N-acetylcysteine would improve survival. Mortality was not significantly lower in the prednisolone–N-acetylcysteine group than in the prednisolone-only group at 6 months (27% vs. 38%). Mortality was significantly lower at 1 month (8% vs. 24%) but not at 3 months (22% vs. 34%). Death due to the hepatorenal syndrome was less frequent in the prednisolone–N-acetylcysteine group than in the prednisolone-only group at 6 months (9% vs. 22%). Although combination therapy with prednisolone plus N-acetylcysteine increased 1-month survival among patients with severe acute alcoholic hepatitis, 6-month survival, the primary outcome, was not improved. (143 words/77 sec = 111 wpm)
Refered Blog
- 内科開業医のお勉強日記「重症アルコール性肝炎：グルココルチコイド＋Ｎ－アセチルシステイン治療 １ヶ月後死亡率改善」
0 件のコメント:
コメントを投稿