NEJM Audio Summary - Nov 8, 2012

先日３例目の感染者が公表された新型コロナウイルス感染症の記事です。

7:37| "Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia", by Ali M. Zaki from the Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia. On June 24, a 60-year-old man died of progressive respiratory infection in Saudi Arabia. The previously unknown coronavirus was isolated from the sputum of a man who had presented with acute pneumonia and subsequent renal failure with a fatal outcome. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses. In this ariticle, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
 In editorial, Larry Anderson, from Emory Children Center, Atlanta, Georgea writes that The global community was apparently not aware of the first case of HCoV-EMC infection until it was reported on ProMED, a website for monitoring emerging diseases, on September 20, approximately 3 months after the patient died. Luckily, there have been no new reports of cases since September 22, but local surveillance should continue. With no evidence of human-to-human transmission, the WHO currently recommends no heightened global surveillance for this virus but continued “routine surveillance for early detection and rapid response of all potential public health threats.” However, such cases provide an opportunity to reconsider response strategies. (255 words / 124 sec = 123 wpm)