NEJM Audio Summary - March 29, 2012

Excerpted Script

7'44"| "Lifestyle Change and Mobility in Obese Adults with Type 2 Diabetes" by  W. Jack Rejeski, from Wake Forest University, Winston-Salem, North Carolina.
This trial investigated whether an intensive lifestyle intervention to produce weight loss and increased fitness would slow loss of mobility among obese patients with type 2 diabetes.  At year 4, among 2514 adults in the lifestyle-intervention group, 20.6% had severe disability and 38.5% had good mobility; the numbers among 2502 participants in the support group were 26.2% and 31.9%, respectively. The lifestyle-intervention group had a relative reduction of 48% in the risk of loss of mobility, as compared with the support group. Both weight loss and improved fitness (as assessed on treadmill testing) were significant mediators of this effect. Adverse events that were related to the lifestyle intervention included a slightly higher frequency of musculoskeletal symptoms at one year. Weight loss and improved fitness slowed the decline in mobility in overweight adults with type 2 diabetes.

雨で雪もだいぶ解けたことだし、そろそろジョギング再開ですね。